Assoc. Prof. Ivaylo Dimitrov PhD

 

Assoc. Prof. Ivaylo Dimitrov, PhD

 

Position:

Head of  Phase Formation, Crystalline and Amorphous Materials Dept.

Secretary of Scientific Council

 

Email:

idimitrov at ipc.bas.bg

 

Room:

416

 

Organizational Unit (Department, Group, Facility):

 

Main research area and subareas:

  • Nucleation and growth of protein crystals
  • Aggregation phenomena in solutions
  • Phase transitions
  • Methods for crystallization

Selected Publications:

 

  • Ivaylo L. Dimitrov, "Narrow size distribution of lysozyme crystals in a reverse vapor diffusion set-up", CrystEngComm, 25, 1471–1478, 2023.
  • Ivaylo L. Dimitrov, "Temperature-dependent growth of protein crystals with temperature-independent solubility: case study of apoferritin", CrystEngComm, 22, 4478–4488, 2020.
  • Ivaylo L. Dimitrov, "Crystal nucleation from solutions of proteins with temperature-independent solubility: a case study of apoferritin", CrystEngComm, 21, 1279–1287, 2019.
  • Ivaylo L. Dimitrov, Dobryana P. Koleva, Feyzim V. Hodzhaoglu, “A view on the aggregation issue in lysozyme crystallization”, CrystEngComm, 18, 7095–7103, 2016.
  • Ivaylo L. Dimitrov, Feyzim V. Hodzhaoglu, Dobryana P. Koleva, “Probabilistic approach to lysozyme crystal nucleation kinetics”, J. Biol. Phys., 41, 327-338, 2015.
  • I. Dimitrov, F. Hodzhaoglu, I. Ivanov, “In Vitro Dissolution of Insulin Crystal Polymorphs at Model Conditions Relevant to In Vivo Environment”, Dissolution Technologies, 20(4), 11-16, 2013.
  • I. Dimitrov, "Aspects of Protein Crystal Nucleation and Growth in Forced Sedimentation", Journal of Scientific Review, 4(1), 189-195, 2012.
  • I. Dimitrov and C. Nanev, “Sedimentation as a tool for crystallization from protein mixtures”, Cryst. Res. Technol., 41(11), 1063–1066, 2006.
  • C. N. Nanev, I. L. Dimitrov, F. V. Hodzhaoglu, “Growth of rhombohedral insulin crystals and in vitro modeling of their dissolution in the bloodstream“, Cryst. Res. Technol., 46(2), 119-126, 2011.
  • C. Nanev and I. Dimitrov, “Layered crystals of apo- and holoferritin grown by alternating crystallization”, Cryst. Res. Technol., 44(9), 908–914, 2009.
  • C. Nanev and I. Dimitrov, “Probabilistic approach to protein crystal nucleation”, Cryst. Res. Technol., 42(5), 440-444, 2007.
  • C. Nanev, I. Dimitrov, F. Hodjaoglu, “Hypergravity as а crystallization tool“, Ann. N.Y. Acad. Sci. 1077, 172-183, 2006.
  • C. Nanev, I. Dimitrov, D. Tsekova, "Adhesion of protein crystals: Measurement of the detachment force“, Cryst. Res. Technol., 41(5), 505–509, 2006.
  • A. Penkova, O. Gliko, I. Dimitrov, F. Hodjaoglu, C. Nanev, P. Vekilov, "Enhancement and suppression of protein crystal nucleation due to electrically-driven convection”, J. Cryst. Growth, 275(1-2), e1527-e1532, 2005.
  • A. Penkova, I. Dimitrov, C. Nanev, “Nucleation of insulin crystals in a wide continuous supersaturation gradient“, Ann. N.Y. Acad. Sci., 1027, 56-63, 2004.
  • C. N. Nanev, F. V. Hodzhaoglu, I. L. Dimitrov, “Kinetics of insulin crystal nucleation, energy barrier and nucleus size“, Cryst. Growth Des., 11(1), 196-202, 2011.
  • F.V. Hodzhaoglu, M. Conejero-Muriel, I.L. Dimitrov, J.A. Gavira, “Optimization of the classical method for nucleation and growth of rhombohedral insulin crystals by pH titration and screening, Bulgarian Chemical Communications, 48, Special Issue A, 29-37, 2016.